Shared T cell receptor chains in blood memory CD4+ T cells of narcolepsy type 1 patients
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چکیده
منابع مشابه
CD4+ T-Cell Reactivity to Orexin/Hypocretin in Patients With Narcolepsy Type 1
Introduction Narcolepsy type 1 is accompanied by a selective loss of orexin/hypocretin (hcrt) neurons in the lateral hypothalamus caused by yet unknown mechanisms. Epidemiologic and genetic associations strongly suggest an immune-mediated pathogenesis of the disease. Methods We compared specific T-cell reactivity to orexin/hcrt peptides in peripheral blood mononuclear cells of narcolepsy type...
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ژورنال
عنوان ژورنال: Journal of Autoimmunity
سال: 2019
ISSN: 0896-8411
DOI: 10.1016/j.jaut.2019.03.010